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Nautilus Biotechnology

Manufacturing Technician

$71k – $104k/yr San Carlos, US on-site full time mid Mar 20, 2026

About this role

At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome – one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing hard scientific problems with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines. We are hiring a Manufacturing Technician to join our growing team. This technician will support the assembly and build of our instrument platform. This role will focus on hands-on assembly of complex electromechanical systems including mechanical structures, fluidic systems, and internal electrical wiring within a complex instrument chassis. The Manufacturing Technician will play a critical role in executing prototype and pilot builds, supporting the transition from engineering development to scalable manufacturing. The ideal candidate is comfortable working in a fast-paced development environment and has experience assembling complex scientific or electromechanical instrumentation. Responsibilities - Perform hands-on assembly of complex electromechanical instruments - Assemble mechanical chassis, structural components, and internal subassemblies - Install and route fluidic systems, including tubing, manifolds, pumps, and valves - Install and route electrical wiring and harnesses within instrument enclosures - Integrate mechanical, electrical, and fluidic subsystems within the instrument chassis - Execute engineering prototype builds, design verification builds, and pilot production builds - Follow detailed work instructions and assembly procedures - Verify correct installation and alignment of components during assembly - Escalate assembly issues or deviations to engineering or operations teams - Support troubleshooting and rework activities when required - Complete required manufacturing documentation including Device History Records (DHR), build travelers, traceability records - Record serial numbers and part traceability information - Document deviations or observations during builds - Provide redlines or suggested improvements to assembly instructions - Provide feedback to engineering and operations teams regarding build challenges or assembly issues - Document observations that may improve manufacturability or assembly efficiency - Support continuous improvement of assembly processes during pilot builds Requirements - 3–7+ years of experience assembling complex electromechanical systems - Experience working with mechanical assemblies, fluidics, and electrical wiring - Experience working in prototype, NPI, or pilot manufacturing environments - Preferred industries include: - Biotechnology / life sciences instrumentation - Medical devices - Analytical instrumentation - Semiconductor equipment - Aerospace instrumentation Additional Requirements - Strong attention to detail and assembly quality - Ability to work independently after initial training - Comfortable working in a fast-paced development environment - Ability to identify and escalate build issues quickly - Strong communication skills and ability to work cross-functionally with engineering teams
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